Hexanoic acid production from lignocellulosic hydrolysates via simultaneous glucose–xylose utilization by carbon catabolite repression-relaxed Clostridium sp. JS66 with in situ adsorption

Q: What does this research mean for the field?

A newly developed carbon catabolite repression-relaxed Clostridium sp. JS66 strain, combined with in situ adsorption, enables high-yield hexanoic acid production (38.63 g/L) from lignocellulosic hydrolysates via simultaneous glucose and xylose utilization. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Kweon Hwan Jung; Jaegeon Lee; Jeongchan Lee; Jung Ho Ahn; Ja Kyong Ko; Gyeongtaek Gong; Sun-Mi Lee; Sung Ok Han; Youngsoon Um

doi:10.1016/j.biortech.2026.134986

May 1, 2026Bioresource TechnologyOpen Access

Hexanoic acid production from lignocellulosic hydrolysates via simultaneous glucose–xylose utilization by carbon catabolite repression-relaxed Clostridium sp. JS66 with in situ adsorption

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Key Points

To produce hexanoic acid from lignocellulosic hydrolysates using a CCR-relaxed Clostridium strain.
Developed CCR-relaxed Clostridium sp. JS66 through adaptive laboratory evolution (ALE) and random mutagenesis.
Analyzed genomics for mutations affecting sugar metabolism.
Implemented in situ adsorption using SP850 during fermentation.
Achieved hexanoic acid production of 38.63 g/L in fed-batch fermentation with mixed sugars.
Demonstrated successful utilization of lignocellulosic hydrolysates by the CCR-relaxed strain.
In situ adsorption effectively reduced inhibition related to hexanoic acid.

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Implication

Finds efficient hexanoic acid production in fermentation with lignocellulosic hydrolysates, suggesting innovative biofuel strategies.

Abstract

• CCR-relaxed Clostridium sp. JS66 was developed via ALE and random mutagenesis. • Genome resequencing revealed mutations linked to sugar metabolism. • In situ adsorption using SP850 mitigated HA-associated inhibition. • HA production reached 38.63 g/L in fed-batch fermentation with mixed sugars. • The CCR-relaxed strain successfully produced HA from lignocellulosic hydrolysates.

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Jung et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7e2f0307b7850943107f https://doi.org/10.1016/j.biortech.2026.134986

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Hexanoic acid production from lignocellulosic hydrolysates via simultaneous glucose–xylose utilization by carbon catabolite repression-relaxed Clostridium sp. JS66 with in situ adsorption

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Abstract

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Hexanoic acid production from lignocellulosic hydrolysates via simultaneous glucose–xylose utilization by carbon catabolite repression-relaxed Clostridium sp. JS66 with in situ adsorption

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Abstract

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