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May 30, 2026Scientific ReportsOpen Access

Triglyceride-glucose index as a marker of metabolic and inflammatory risk across different thyroid function states

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Authors

ÜDÜmran Karabulut DoğanSASefer Aslan

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Overview

Cross-sectional study investigates associations of the triglyceride-glucose index with metabolic risk in thyroid conditions, suggesting its relevance despite thyroid status.

Key Points

  • This study investigates the relationship between the triglyceride-glucose index and metabolic risk across various thyroid function states.
  • 222 adults categorized by thyroid function (overt hypothyroidism, subclinical hypothyroidism, euthyroidism, healthy controls)
  • TyG index calculated using fasting glucose and triglyceride values
  • Receiver operating characteristic analysis conducted to assess TyG index's discriminative ability for metabolic risk.
  • TyG index showed no significant differences across thyroid function groups (p = 0.152)
  • Significant positive correlations were found between TyG index and triglyceride levels (r = 0.419, p < 0.001)
  • ROC analysis indicated moderate performance (AUC = 0.731; 95% CI: 0.652-0.809) in identifying metabolic risk.

Cite This Study

Doğan et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7ecb0307b785094315cfhttps://doi.org/10.1038/s41598-026-50447-9
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