Rosiglitazone Alleviates Parkinson's Disease Phenotypes of Drosophila via dCTP-mediated Inhibition of AGE-RAGE Pathway

Yubing Kang; Yanrong Yang; Zumeng Wang; Yuin Chang; Ning Wang; Jie Yang; Kahleong Lim; Fengwei Yu; Mingyu Wang; Li Li; C M Zhang

doi:10.1016/j.neuropharm.2026.111047

May 1, 2026NeuropharmacologyOpen Access

Rosiglitazone Alleviates Parkinson's Disease Phenotypes of Drosophila via dCTP-mediated Inhibition of AGE-RAGE Pathway

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Key Points

This research aims to explore the effects of rosiglitazone on Parkinson's disease characteristics in Drosophila.
Examined lipid droplet accumulation in Parkinson's disease Drosophila models
Assessed the impact of rosiglitazone treatment on dCTP levels
Analyzed the inhibition of the AGE-RAGE pathway after rosiglitazone administration.
Rosiglitazone reduced lipid droplet accumulation in Drosophila and improved Parkinson's disease phenotypes
Rosi treatment led to increased dCTP levels and significant inhibition of the AGE-RAGE pathway.

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Implication

Shows rosiglitazone alleviates Parkinson’s disease symptoms in Drosophila, suggesting potential therapeutic benefits.

Abstract

• Lipid droplets (LDs) over accumulated in Parkinson’s disease (PD) drosophila. • Rosiglitazone (Rosi) ameliorated LDs accumulation and phenotypes of PD drosophila. • Rosi increased dCTP content and inhibited the AGE-RAGE pathway in PD. • Rosi and dCTP held potential for treatment of PD.

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Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7fef0307b7850943206f https://doi.org/10.1016/j.neuropharm.2026.111047

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Rosiglitazone Alleviates Parkinson's Disease Phenotypes of Drosophila via dCTP-mediated Inhibition of AGE-RAGE Pathway

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Abstract

Discussion

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Rosiglitazone Alleviates Parkinson's Disease Phenotypes of Drosophila via dCTP-mediated Inhibition of AGE-RAGE Pathway

Key Points

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Implication

Abstract

Discussion

Cite This Study

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