Endometrial cancer mortality among postmenopausal women in the United States, 1999-2023.

e17621 Background: Endometrial cancer occurs predominantly in postmenopausal women, driven by hormonal imbalance and metabolic comorbidities associated with aging. Despite favorable prognosis with early detection, it remains a notable cause of mortality, underscoring the importance of examining disease patterns and trends in this population. Methods: Mortality data from the CDC WONDER multiple cause of death database were used to examine endometrial cancer–related deaths among postmenopausal women aged ≥45 years. Deaths were identified using ICD-10 code C54.1. Crude and age-adjusted mortality rates (CMRs and AAMRs) per 100,000 population were calculated and stratified by year, age group, race/ethnicity, and geographic region. Temporal trends were assessed using Joinpoint regression to estimate annual percent change (APC) and average annual percent change (AAPC) with 95% confidence intervals. Results: A total of 125,096 deaths related to endometrial cancer were reported among postmenopausal women. Most deaths occurred among individuals aged 65–85+ years (91,818) and at the decedent's home (38.8%). The AAMRs increased significantly from 6.88 (95% CI: 6.65–7.11) in 1999 to 12.03 (95% CI: 11.78–12.29) in 2023, with an average annual percent change (AAPC) of 2.18 (95% CI: 1.36–3.02; p < 0.000001) .Trend analysis showed an initial decline from 1999 to 2014 (APC = −0.56%), followed by a sharp increase until 2017 (APC = 13.19%), with a continued significant rise through 2023 (APC = 3.94%). The highest mortality rates were observed among non-Hispanic Black/African American individuals, followed by non-Hispanic White and Hispanic/Latino populations. Geographic disparities were evident, with the Northeast experiencing the highest burden, while the West was the least affected. Non-metropolitan regions consistently exhibited higher AAMRs than metropolitan areas (7.63 vs. 7.06).From 1999 to 2023, Columbia ranked in the 90th percentile for mortality rates among U.S. states. Conclusions: Endometrial cancer remains a major health burden among postmenopausal women, with the highest mortality observed in older postmenopausal women. Deaths and age-adjusted mortality rates (AAMRs) per 100,000 for trends related to cancer among postmenopausal women from 1999 to 2023. Variable Deaths AAMR (95%CI) 1999 AAMR (95% CI)2023 Female 125,096 6.88(6.6 to 7.11) 12.03 (11.78 to 12.29) NH Whites 92,898 6.27 (6.03 to 6.5) 9.98 (9.73 to 10.24) NH Blacks 20,786 9.83 (8.95 to 10.72) 17.96(17.08 to 18.83) Northeast 27,363 6.89 (6.41 to 7.37) 10.84 (10.32 to 11.37) West 24,178 5.77 (5.31 to 6.22) 9.66 (9.21 to 10.12) Metro 82,548 (2020) 6.81 (6.57 to 7.01) (2020) 10.98 (10.72 to 11.24) Non-metro 17,334 7.19 (6.64 to 7.74) 11.51 (10.88 to 12.14)