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May 30, 2026Journal of Clinical Oncology

G8 geriatric score as a determinant of survival and treatment in metastatic breast cancer.

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Authors

MAMehdi AlemSNSara NejjariMBMounir Belcadi

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Overview

Retrospective cohort study evaluates G8 score's impact on treatment and survival in elderly women, indicating potential for improved care.

Key Points

  • The study aims to evaluate how the G8 geriatric score correlates with treatment patterns and survival outcomes in elderly women with metastatic breast cancer.
  • Conducted a retrospective cohort study with 93 women aged ≥70 years diagnosed with metastatic breast cancer.
  • Performed baseline G8 assessments and classified patients into impaired (≤14) or non-impaired (>14) groups.
  • Collected clinical, pathological, and therapeutic data to analyze correlations.
  • Median progression-free survival (PFS) was 14.6 months in the non-impaired group vs. 7.2 months in the impaired group (HR 1.89; 95% CI: 1.21–2.95; p = 0.002).
  • Median overall survival (OS) was 38.5 months for G8 > 14 vs. 18.7 months for G8 ≤14 (HR 2.31; 95% CI: 1.42–3.75; p < 0.001).
  • G8 impairment independently correlated with poorer OS (HR 2.08; 95% CI: 1.27–3.41; p = 0.004) after adjusting for other factors.

Cite This Study

Alem et al. (2026) studied this question.

synapsesocial.com/papers/6a1a80550307b7850943247fhttps://doi.org/10.1200/jco.2026.44.16_suppl.e24121
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1G8 screening-defined geriatric vulnerability as a predictor of survival and quality of life in older patients with advanced cancer treated with novel therapies.2026
  2. 2Clinical utility of the Geriatric-8 in the functional assessment of patients with gynecological cancer aged 75 and older: a retrospective study2026
  3. 3Prognostic associations of the G8 geriatric screening tool in the EORTC Brain Tumor Group trials 1608 and 1709 in patients with newly diagnosed glioblastoma.2026
  4. 4QOL-22. Prognostic associations of the G8 geriatric screening tool in the EORTC Brain Tumor Group trials 1608 and 1709 in newly diagnosed glioblastoma2025
  5. 5The prognostic role of Geriatric 8 in patients with cancer: a meta-analysis and systematic review2025 · 15 citations