MXene-Based Terahertz Metamaterial Biosensors: From Laboratory Simulation to Clinical Application

Terahertz (THz) metamaterial biosensors have emerged as a powerful platform for label-free, non-ionizing biodetection, yet their clinical translation is severely hindered by limited sensitivity, poor anti-interference capability, and a fragmented research chain that rarely extends beyond simulation. Two-dimensional transition metal carbides/nitrides (MXenes) offer a transformative alternative to conventional gold-based metamaterials, providing metal-like high conductivity, abundant surface functional groups for specific biomolecular capture, excellent biocompatibility, and mechanical flexibility. This review systematically examines the recent progress of MXene-based THz metamaterial biosensors, covering structural design strategies, material synergistic system, machine learning-assisted optimization, and performance evaluation metrics. While most studies remain in the simulation stage, a landmark in vivo validation by Yang et al. achieved real-time thrombus monitoring with 94.7% sensitivity and 92.3% specificity, bridging the gap between simulation and clinical application. We identified key bottlenecks hindering clinical translation and propose future directions toward clinically adaptive, full-chain development. This review provides a roadmap for transitioning MXene-based THz biosensors from laboratory simulation to practical point-of-care diagnostics.