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May 30, 2026Organic Letters

Rapid Access to Human Milk Oligosaccharide Analogues through a Partially Protected N -Acetylglucosamine Donor

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Authors

QWQing WangQZQian ZhangLYLiran Yang

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Overview

Randomized trial explores glycosyl donor's efficiency in synthesizing oligosaccharides, highlighting ease of production.

Key Points

  • The aim is to develop a simplified method for synthesizing human milk oligosaccharides using a novel glycosyl donor.
  • Utilized a gold(I)-catalyzed approach to synthesize HMO-related saccharides using a partially protected glycosyl donor.
  • Investigated the impact of protecting-group patterns on glycosylation efficiency using various galactosyl acceptors.
  • Demonstrated site-selective glycosylation and further modification of the core disaccharide.
  • Achieved efficient formation of β-GlcNAc-(1→3)-Gal motif with specific protective groups.
  • Showed that the presence of a 2-O-benzyl group is essential for effective glycosylation.
  • Successfully diversified the core disaccharide through site-selective glycosylation techniques.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a1a818e0307b78509433765https://doi.org/10.1021/acs.orglett.6c01620
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