Randomized trial examines trends in histological composition and causes of mortality in patients with orbital cancer, highlighting shifting patterns and implications for care.
Key Points
This study aims to analyze the histological distribution and causes of mortality in patients with primary malignant orbital cancers.
Analyzed data from the SEER Research Plus database for patients diagnosed with malignant orbital tumors between 2000 and 2022.
Histological subtypes were classified into MALT lymphomas, non-MALT lymphomas, epithelial malignancies, and others.
Cancer-specific mortality was assessed using Fine-Gray competing risk regression.
Among 2,154 patients, MALT lymphomas were the most common histological subtype (48.6%).
15.3% of patients died from orbital cancer; non-cancer causes like cardiovascular disease were significant competing risks.
Cancer-specific mortality was highest among epithelial malignancies and linked to increasing age and lack of surgery among those cases.