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May 30, 2026Journal of Clinical Oncology

Sociodemographic disparities in sepsis-associated mortality among patients with gastrointestinal malignancies in the United States, 1999-2020.

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Authors

TKTehrim KhanASAhsun Rizwan SiddiqiAZAmna Zaheer

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Overview

Randomized trial evaluating sepsis-associated mortality trends in gastrointestinal malignancy patients, indicating significant sociodemographic disparities.

Key Points

  • This study aims to evaluate long-term trends in sepsis-associated mortality among patients with gastrointestinal malignancies while exploring sociodemographic disparities.
  • Analyzed U.S. death certificate data from CDC WONDER database (1999–2020)
  • Included adults aged ≥25 years with gastrointestinal malignancies indicated as underlying cause of death and sepsis as a contributing cause
  • Calculated age-adjusted mortality rates and assessed temporal trends using Joinpoint regression
  • Sepsis-associated mortality increased from 2.98 in 1999 to 3.35 in 2020 (AAPC 0.83%, 95% CI 0.44–1.22)
  • Males showed significantly higher mortality rates compared to females (3.82 vs 2.22), with the largest increase occurring between 2012 and 2020 (APC 2.62, 95% CI 1.84–3.40)
  • African Americans had the highest AAMR of 4.77 compared to other racial groups, while rural populations experienced the greatest increase in mortality over time (AAPC 1.81%, 95% CI 1.25–2.38)

Cite This Study

Khan et al. (2026) studied this question.

synapsesocial.com/papers/6a1a82b80307b7850943458bhttps://doi.org/10.1200/jco.2026.44.16_suppl.e23077
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mortality trends from sepsis and gastrointestinal cancer among United States adults: A CDC WONDER–based analysis.2026
  2. 2National trends in sepsis-related mortality among decedents with malignant neoplasms in the United States, 1999–2023.2026
  3. 3Trends in sepsis-related mortality among adults with cancer aged ≥ 25 years in United States, 1999-2020: A CDC WONDER study.2026
  4. 4Sepsis-related mortality in adults with liver and intrahepatic bile duct malignancies: A 25-year national analysis of trends and disparities, 1999-2023.2026
  5. 5Trends and disparities in sepsis-related mortality among patients with lung cancer: A 25-year nationwide analysis.2026