In Vivo Optical Imaging of Amyloid Aggregates in Brain: Design of Fluorescent Markers

Routine diagnostics and studies of Alzheimer's disease might benefit form the noninvasive optical imaging of amyloid-β plaques in the brain. A rational design strategy for in vivo amyloid-imaging agents that enter the brain and selectively stain amyloid plaques is presented (see picture), and properties of a promising lead biomarker candidate are reported. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂002/2005/z500845ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.