Editorial: Nanodomain regulation of muscle physiology and alterations in disease

Cardiac, skeletal and smooth muscle are vastly different in their function and structure. However, in all three types of muscle, calcium ions (Ca2+) serve as the primary second messenger controlling contraction, and this function is modulated by the autonomic nervous system. Disruption of Ca2+ signalling and muscle function are evident in pathologies linked to both inherited and acquired conditions, including hypertension, diabetes, muscular dystrophy, and heart disease. Evidence has shown that remodelling of Ca2+ signalling nanodomains, as well as other signalling cascades, contribute to these pathological changes. However, our understanding of these mechanisms remains in its infancy. More information is needed to further our comprehension of nanoscale cellular physiology and develop treatments to counteract the changes that occur in disease. This Research Topic has collected 11 high-quality papers from authors focusing on nanodomains and alterations in disease.