Key result
Layer-specific echocardiography showed impaired cardiac strain and microcirculation perfusion in all layers of DCM patients, with longitudinal strain correlating with perfusion (r=0.690, p<0.01).
Why the study?
To investigate the pattern of LV function and myocardial perfusion and their relationship in dilated cardiomyopathy patients using layer-specific STI and layer-specific MCE.
Do layer-specific speckle tracking imaging and myocardial contrast echocardiography detect impaired myocardial deformation and microcirculation in patients with dilated cardiomyopathy compared to controls?
Case-Control (n=60)
Do layer-specific speckle tracking imaging and myocardial contrast echocardiography detect impaired myocardial deformation and microcirculation in patients with dilated cardiomyopathy compared to controls?
Answers are grounded in this paper and cite their sources.
Combined layer-specific speckle tracking and myocardial contrast echocardiography reveals that both myocardial deformation and microcirculation perfusion are impaired across all myocardial layers in patients with dilated cardiomyopathy.
Aim To investigate the pattern of left ventricular (LV) function and myocardial perfusion and their relationship in dilated cardiomyopathy (DCM) patients using layer‐specific speckle tracking imaging (STI) and layer‐specific myocardial contrast echocardiography (MCE). Material and Methods Thirty DCM patients and 30 controls were recruited and underwent STI and MCE examination. The peak values of longitudinal strain (LS), circumferential strain (CS) of each layer of LV were recorded and compared between groups. Additionally, cross‐sectional area of a microvessel (A) and average myocardial microvascular lesion (β) of each layer were measured, myocardial blood flow (MBF) was estimated using A × β, above parameters were compared between two groups. Results The LS of endo‐ (LS endo ), mid‐ (LS mid ) and epicardium (LS epi ), as well as CS of endo‐ (RS endo ), mid‐ (RS mid ), (LS epi ) epicardium and LS endo/epi, CS endo/epi were significantly decreased in DCM patients. More importantly, DCM patients demonstrated decreased A, β and A × β in all three myocardium layers and A endo/epi, β endo/epi, A × β endo/epi compared to the controls. The time to peak and the cardiac cycle required to reach the peak were prolonged in DCM patients ( p < 0.05). Longitudinal strain parameters of each layer had a negative relationship with perfusion parameter A and this relationship was strongest between LSendo and Aendo ( r = 0.690, p < 0.01). Conclusions The cardiac strain and, more importantly, coronary microcirculation perfusion was impaired in each layer in DCM patients. The longitudinal function of the LV myocardium was closely related to changes in myocardial microcirculation perfusion.
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Tang et al. (2022) conducted a case-control in Dilated cardiomyopathy (DCM) (n=60). Layer-specific speckle tracking imaging (STI) and myocardial contrast echocardiography (MCE) vs. Healthy controls was evaluated on Left ventricular function and myocardial perfusion parameters (r = 0.690, p=< 0.01). Layer-specific echocardiography showed impaired cardiac strain and microcirculation perfusion in all layers of DCM patients, with longitudinal strain correlating with perfusion (r=0.690, p<0.01).
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