History and Future of Growth Hormone Research

The understanding of the mechanisms of growth hormone (GH) action has seen great accomplishments over the last two decades. These achievements include the cloning of a variety of GH and GH receptor (GHR) genes and cDNAs; solving of the three-dimensional structure of GH and the GH/GHR complex, and the discovery of GH antagonists. These GH antagonists have resulted in a new class of drugs with important clinical implications. Animal models in which the GH/insulin-like growth factor (IGF)-I axis has been perturbed also have resulted in many novel findings. We have now entered the era of genomics and proteomics. Genes and proteins that are up- or downregulated as a function of GH action (or lack thereof) will add to the repertoire of knowledge that will lead to a better understanding of the molecular basis of GH action.