Each 1% increase in HbA1c or each year increase in duration of type 2 diabetes mellitus was associated with approximately 30% increased odds of a thicker carotid intima-media thickness.
Observational (n=129)
Do duration of diabetes, glycemic control, and traditional cardiovascular risk factors predict increased carotid IMT in adolescents and young adults with type 2 diabetes mellitus?
In youth with type 2 diabetes, poorer glycemic control and longer disease duration are independently associated with increased carotid intima-media thickness, highlighting the need for early risk factor management.
Effect estimate: OR ~1.30
BACKGROUND: Carotid intima-media thickness (IMT) provides a mechanism for detecting early atherosclerosis. Little information is available concerning carotid IMT and the progression of atherosclerosis in adolescents and young adults with type 2 diabetes mellitus. OBJECTIVE: We sought to determine the factors that contribute to early changes in carotid IMT in youth with type 2 diabetes mellitus and to identify any predictors of increased carotid IMT. METHODS: Demographic, anthropometric, laboratory data and carotid imaging were obtained in 129 youth of mixed ethnicity, ages 10-23 yr. Associations of carotid IMT outcomes and risk variables were analyzed by regression analysis. Logistic regression was performed to elucidate independent determinants that predict a worse carotid IMT. RESULTS: Carotid IMT increased with higher glycosylated hemoglobin (HbA1c) levels and longer duration of diabetes. Regression modeling showed that HbA1c and duration of diabetes in the presence of traditional cardiovascular risk factors (male sex, LDL cholesterol, and blood pressure) were independent determinants of carotid IMT. Logistic regression analysis demonstrated that each 1% increase in HbA1c or each year increase in duration of type 2 diabetes mellitus is associated with approximately 30% increased odds of a thicker carotid IMT. CONCLUSIONS: Poorer glycemic control and longer disease duration have independent adverse effects on carotid IMT in youth with type 2 diabetes mellitus. These adverse effects appear to be more prominent in males. Developing effective strategies to improve blood glucose control in youth with type 2 diabetes mellitus is essential to prevent or limit the development and progression of atherosclerotic cardiovascular disease.
Shah et al. (Wed,) conducted a observational in Type 2 diabetes mellitus (n=129). HbA1c and duration of diabetes was evaluated on Carotid intima-media thickness (IMT) (OR ~1.30). Each 1% increase in HbA1c or each year increase in duration of type 2 diabetes mellitus was associated with approximately 30% increased odds of a thicker carotid intima-media thickness.