Key result
Computer simulation of acute myocardial ischemia showed that basic stimuli elicit depressed fast responses supported by Na+ current, while premature stimuli cause Ca2+-dependent slow responses.
Computer simulations demonstrate that premature stimuli during acute regional ischemia can trigger Ca2+-dependent slow response action potentials in the ischemic central zone.
Does not support clinical inferences from simulations alone; leaves open experimental validation of ischemia-related arrhythmia mechanisms.
In this work, computer simulation has been used to study the main features of action potentials (APs) elicited in myocardial tissue when regional acute ischemia is present. For this purpose, the Luo-Rudy (phase II) model of the cardiac AP has been used with the formulation of the ATP-sensitive K/sup +/ current by Ferrero et al. (1996) being adopted. Simulations of APs were carried out in a linear strand of 300 cardiac cells, which comprised three zones that represented the normal zone, borderzone and ischemic central zone which appear during regional ischemia. The authors' results show that: (a) basic stimuli elicit APs which correspond to depressed fast responses, with the upstroke being supported mainly by Na/sup +/ current; and (b) a premature stimulus gives rise to APs which are Ca/sup 2+/ dependent (slow responses) within the ischemic central zone.
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Ferrero et al. (2002) studied Acute myocardial ischemia. Computer simulation of regional acute ischemia was evaluated on Action potentials elicited by basic and premature stimuli. Computer simulation of acute myocardial ischemia showed that basic stimuli elicit depressed fast responses supported by Na+ current, while premature stimuli cause Ca2+-dependent slow responses.
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