Key result
NT-proBNP accurately diagnosed left ventricular dysfunction in patients with AECOPD (AUC 0.95 vs 0.67 for troponin T), with left-heart involvement independently increasing NT-proBNP (OR 74; P=0.0001).
Why the study?
Do NT-proBNP and troponin T accurately diagnose left ventricular dysfunction in patients admitted to the ICU for acute exacerbation of COPD?
Observational (n=148)
Do NT-proBNP and troponin T accurately diagnose left ventricular dysfunction in patients admitted to the ICU for acute exacerbation of COPD?
NT-proBNP is highly accurate for ruling out left ventricular dysfunction in patients presenting with severe exacerbations of COPD.
Answers are grounded in this paper and cite their sources.
May aid exclusion of LV dysfunction in severe AECOPD; hypothesis-generating and requires prospective validation before adoption.
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Abroug et al. (2006) conducted an observational in Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) (n=148). NT-proBNP and troponin T was evaluated on Diagnosis of AECOPD associated with left ventricular (LV) dysfunction (OR 74, 95% CI 15-375, p=0.0001). NT-proBNP accurately diagnosed left ventricular dysfunction in patients with AECOPD (AUC 0.95 vs 0.67 for troponin T), with left-heart involvement independently increasing NT-proBNP (OR 74; P=0.0001).
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