The TG/HDL ratio was significantly associated with arterial stiffness (adjusted OR 1.15) and proved more informative than other lipid parameters for primary cardiovascular prevention.
Cross-Sectional (n=71,326)
Sí
In a middle-aged population free of cardiovascular disease, the TG/HDL ratio is more strongly associated with arterial stiffness than other lipid parameters, suggesting its potential utility as an early marker of vascular damage in primary prevention.
Estimación del efecto: OR 1.15 (95% CI 1.13-1.17)
valor p: p=<0.001
Background Dyslipidemia contributes to the progression of arterial stiffness (AS). The purpose of this study was to investigate the association of the different lipid parameters with arterial stiffness index (ASI) in a middle-aged population free of cardiovascular (CV) disease. Methods Among 71,326 volunteers from the UK Biobank population, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), lipoprotein (a) Lp(a), apolipoproteins A and B (Apo A and Apo B), and ASI were measured. Values for non-HDL, TC/HDL, TG/HDL, and LDL/HDL were calculated. AS was defined as an ASI 10 m/s. Associations between lipid parameters and ASI were performed using multiple linear logistic regressions. The results reported from univariate models were the squared partial correlation coefficient, r 2 , and from multivariate models, the adjusted coefficient of determination, R 2 , to describe the contribution of ASI variability for each lipid parameter. Results We found that TG/HDL was mainly associated with ASI β = 0.53 (0.01), r 2 = 3.66%, p 0.001 and adjusted β = 0.21 (0.01), R 2 = 13.58%, p 0.001 and AS odds ratio (OR) = 1.86 (1.80–1.92), r 2 = 1.65%, p 0.001 and adjusted OR = 1.15 (1.13–1.17), R 2 = 8.54%, p 0.001 rather than the others. TG/HDL remained the only lipid parameter that showed added value in linear multivariate models. TG/HDL remained less associated with AS than age ( r 2 = 5.55%, p 0.001), mean blood pressure (BP; r 2 = 5.31%, p 0.001), and gender ( r 2 = 4.44%, p 0.001), but more highly associated than body mass index (BMI; r 2 = 1.95%, p 0.001), heart rate (HR; r 2 = 0.81%, p 0.001), fasting glucose ( r 2 = 0.18%, p 0.001), tobacco ( r 2 = 0.05%, p 0.001), and glomerular filtration rate (GFR; r 2 = 0.01%, p 0.001). Conclusions In primary CV prevention, lipids, especially through the TG/HDL ratio, could be more instructive in preventing the increase in AS than other modifiable factors.
Alexandre Vallée (Fri,) conducted a cross-sectional in Primary cardiovascular prevention (free of cardiovascular disease) (n=71,326). TG/HDL ratio vs. Other lipid parameters (LDL, TC, etc.) was evaluated on Arterial stiffness (defined as Arterial Stiffness Index > 10 m/s) (OR 1.15, 95% CI 1.13-1.17, p=<0.001). The TG/HDL ratio was significantly associated with arterial stiffness (adjusted OR 1.15) and proved more informative than other lipid parameters for primary cardiovascular prevention.
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