Why the study?
Does daily neutrophil count variability reflect a 1/f-like (inverse power-law) spectrum in normal subjects?
Does daily neutrophil count variability reflect a 1/f-like (inverse power-law) spectrum in normal subjects?
Daily neutrophil counts in normal subjects exhibit 1/f-like scaling, suggesting that spectral analysis of neutrophil dynamics could have future diagnostic value.
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May support spectral analysis of neutrophil dynamics for future diagnostics; extends 1/f scaling observations but remains hypothesis-generating.
Daily neutrophil counts show considerable variability in normal subjects. The dynamics of these apparently erratic fluctuations have not been characterized. We hypothesized that this variability might reflect the kind of 1/f-like (inverse power-law) spectrum seen in other physiologic processes. Fast Fourier transform analysis of neutrophil count data over 64 consecutive days from four previously reported normal volunteers showed a good fit (r = 0.84; p 0.001) to the predicted power-law regression line (y = -1.14x -1.05). Further characterization of normal and pathologic neutrophil spectra may have diagnostic value.
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Goldberger et al. (1986) studied this question.
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