Women with a history of both hypertensive disorders of pregnancy and hypertension had significantly higher left ventricular mass compared to women with HDP only (99.4 vs 87.7 g, p=0.02).
Cohort (n=346)
Does a history of hypertensive disorders of pregnancy associate with subsequent hypertension, increased LV mass, and myocardial scarring in women with suspected INOCA?
In women with suspected INOCA, a history of hypertensive disorders of pregnancy is associated with a significantly increased risk of subsequent hypertension and, when combined with hypertension, greater left ventricular mass.
Tasa de eventos absoluta: 99.4% vs 87.7%
valor p: p=0.02
Aims Hypertensive disorders of pregnancy (HDP) predict future cardiovascular events. We aim to investigate relations between HDP history and subsequent hypertension (HTN), myocardial structure and function, and late gadolinium enhancement (LGE) scar. Methods and results We evaluated a prospective cohort of women with suspected ischaemia with no obstructive coronary artery disease (INOCA) who underwent stress/rest cardiac magnetic resonance imaging (cMRI) with LGE in the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction study. Self-reported history of pregnancy and HDP (gestational HTN, pre-eclampsia, toxaemia and eclampsia) were collected at enrollment. In our cohort of 346, 20% of women report a history of HDP. HDP history was associated with 3.2-fold increased odds of HTN. Women with a history of both HDP and HTN had higher cMRI measured left ventricular (LV) mass compared with women with HDP only (99.4±2.6 g vs 87.7±3.2 g, p=0.02). While we found a similar frequency of LGE scar, we observed a trend towards increased LGE scar size (5.1±3.4 g vs 8.0±3.4 g, p=0.09) among the women with HDP history compared to women without. Conclusion In a high-risk cohort of women with suspected INOCA, 20% had a history of HDP. Women with HDP history were more likely to develop HTN. Our study demonstrates higher LV mass in women with HDP and concomitant HTN. Although the presence of LGE scar was not different in women with and without HDP history, we observed a trend towards larger scar size in women with HDP. Future studies are needed to better assess the relationship of HDP and cardiac morphology and LGE scarring in a larger cohort of women.
Quesada et al. (Sat,) conducted a cohort in Suspected ischaemia with no obstructive coronary artery disease (INOCA) (n=346). History of hypertensive disorders of pregnancy (HDP) and hypertension vs. History of HDP only was evaluated on Left ventricular mass (p=0.02). Women with a history of both hypertensive disorders of pregnancy and hypertension had significantly higher left ventricular mass compared to women with HDP only (99.4 vs 87.7 g, p=0.02).