Key result
Catheter-based renal denervation initially abolished nerve activity, but by 5.5 and 11 months post-procedure, functional responses to electric stimulation and anatomic distribution returned to normal.
Why the study?
Does catheter-based radiofrequency renal denervation lead to functional and anatomic reinnervation over time in normotensive sheep?
Population
Normotensive anesthetized sheep (n=22)
Comparison
Catheter-based radiofrequency renal denervation… vs Intact renal nerves and immediate…
Design
Preclinical
Follow-up
11 months
Authors
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May challenge durability assumptions for renal denervation; leaves open mechanisms of sustained BP effects and need for human data.
Does catheter-based radiofrequency renal denervation lead to functional and anatomic reinnervation over time in normotensive sheep?
Complete functional and anatomic reinnervation occurs within 5.5 to 11 months after renal denervation in sheep, challenging the assumption that sustained blood pressure reduction in humans is solely due to permanent denervation.
Booth et al. (2014) studied Normotensive sheep (animal model) (n=22). Catheter-based radiofrequency renal denervation vs. Intact renal nerves was evaluated on Level of functional and anatomic reinnervation. Catheter-based renal denervation initially abolished nerve activity, but by 5.5 and 11 months post-procedure, functional responses to electric stimulation and anatomic distribution returned to normal.
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