Key result
Bipolar disorder was associated with a significantly prolonged Tp-e interval and increased Tp-e/QT ratio compared to healthy controls, indicating a potential marker for ventricular arrhythmia risk.
Why the study?
Cardiovascular diseases occur twice as often in bipolar disorder, prompting evaluation of myocardial scarring, arrhythmia markers, and ventricular repolarization in these patients.
Does bipolar disorder increase the risk of ventricular arrhythmias as measured by ventricular repolarization markers and fragmented QRS compared to healthy controls?
Case-Control (n=103)
No
Does bipolar disorder increase the risk of ventricular arrhythmias as measured by ventricular repolarization markers and fragmented QRS compared to healthy controls?
Patients with bipolar disorder exhibit prolonged Tp-e intervals and increased Tp-e/QT ratios, suggesting an increased risk for ventricular arrhythmias.
Answers are grounded in this paper and cite their sources.
Suggests possible arrhythmia vulnerability in bipolar disorder; hypothesis-generating, needs prospective outcome studies.
Aim: Bipolar disorder (BD) is one of the chronic psychiatric diseases. It has been reported that cardiovascular diseases are seen twice as often in patients with BD. Fragmented QRS (fQRS) has been found to be associated with myocardial scarring and is used as a marker of arrhythmia and mortality. Ventricular repolarization (VR) is often evaluated using QT interval and T wave measurement data. In our study, we aimed to evaluate fQRS, QTc interval, QT dispersion (QTd), Tp-e interval, Tp-e/QT ratio results and VR, together with blood biochemistry parameter results of cases with BD.
No takes yet. Share an insight, caveat, or question.
Yağcı et al. (2023) conducted a case-control in Bipolar disorder (n=103). Bipolar disorder (Exposure) vs. Healthy controls was evaluated on Tp-e interval (p=0.018). Bipolar disorder was associated with a significantly prolonged Tp-e interval and increased Tp-e/QT ratio compared to healthy controls, indicating a potential marker for ventricular arrhythmia risk.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: