Key result
Remnant-like particle cholesterol was strongly and independently associated with increased carotid intima-media thickness in newly postmenopausal women (p<0.01), but not in men or other women.
Why the study?
Are remnant lipoproteins associated with increased carotid intima-media thickness in men and women?
Observational (n=296)
No
Are remnant lipoproteins associated with increased carotid intima-media thickness in men and women?
Effect estimate: Regression coefficient 0.007
p-value: p=<0.01
Remnant-like particle cholesterol is strongly associated with carotid atherosclerosis specifically in women 1-7 years post-menopause, suggesting increased sensitivity to atherogenic lipoproteins during this reproductive transition.
Does not support clinical testing or targeting of remnant cholesterol in postmenopausal women; leaves open a menopause-specific atherogenic role requiring prospective validation.
The subclass of triglyceride-rich lipoproteins – remnant-like particles (RLP) seems to be strong and independent risk factor for cardiovascular disease. We evaluated the role of RLP and other risk factors (RF) with sonographically measured intima-media thickness of carotid arteries (IMT CCA) in a cohort of Czech population including women defined according to the time after menopause. We investigated relation of IMT CCA to age, weight, central obesity, plasma lipids including remnant-like particles cholesterol (RLP-C) and triglycerides (RLP-TG) in 136 men and 160 women. Using multiple linear regression analysis, significant association between IMT CCA and RLP-C was found in women 1-7 years after menopause. In the whole group of women, only age and fasting blood glucose were independently associated with IMT CCA. In men only age significantly correlated with IMT CCA. Significant decrease of all plasma lipids between 1988 and 1996 in men was detected, while in women significant increase in triglycerides and no change in non-HDL cholesterol was observed. RLP-C was the strongest independent RF for atherosclerosis in postmenopausal women but its association with IMT CCA was limited to several years after menopause. In conclusion, women changing reproductive status could be more sensitive to atherogenic impact of remnant lipoproteins.
No takes yet. Share an insight, caveat, or question.
Piťha et al. (2015) conducted an observational in Preclinical atherosclerosis (n=296). Remnant-like particles cholesterol (RLP-C) vs. Men and women in other menopausal stages was evaluated on Intima-media thickness of common carotid arteries (IMT CCA) (Regression coefficient 0.007, p=<0.01). Remnant-like particle cholesterol was strongly and independently associated with increased carotid intima-media thickness in newly postmenopausal women (p<0.01), but not in men or other women.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: