Key result
The presence of diabetes mellitus did not have a significant impact on fractional flow reserve values in coronary stenoses of intermediate severity compared to nondiabetic patients (P=0.957).
Why the study?
Does the presence of diabetes mellitus affect FFR measurements in patients with intermediate coronary lesions?
Observational (n=121)
Does the presence of diabetes mellitus affect FFR measurements in patients with intermediate coronary lesions?
The presence of diabetes mellitus does not significantly impact FFR values in intermediate coronary stenoses, suggesting FFR remains a reliable physiological assessment tool in this population.
Answers are grounded in this paper and cite their sources.
Supports FFR reliability in diabetics with intermediate stenoses; leaves open prospective confirmation before broader adoption.
BACKGROUND: Fractional flow reserve (FFR) is an invasive method to assess the functional significance of coronary stenoses. The value of FFR in diabetic patients is controversial because of microvascular dysfunction. The aim of this study is to investigate the effect of diabetes mellitus (DM) on FFR measurements. METHODS: One hundred and twenty-one patients with an intermediate lesion who had undergone FFR measurement were included in the study. Lesion severity was determined by quantitative coronary angiography. The patients were divided into groups according to the presence (group 1) or absence (group 2) of DM. The patients were further categorized according to the degree of luminal narrowing caused by the lesion (40-50, 51-60, and >60%) and reference vessel diameter (> or = 2.8 and <2.8 mm). FFR measurements were compared in each category. RESULTS: There was no difference between the FFR values of diabetic and nondiabetic patients who had coronary lesions with similar degree of luminal narrowing (0.87+/-0.08 vs. 0. 0.85+/-0.07; 0.81+/-0.08 vs. 0.82+/-0.10; 0.81+/-0.10 vs. 0.83+/-0.09, P = 0.957). In the analysis comparing FFR measurements in the categories set according to reference vessel diameter, we did not find a difference either (0.82+/-0.09 vs. 0.83+/-0.09; 0.84+/-0.09 vs. 0.82+/-0.09, P = 0.878). The DeltaFFR value, which is the difference between FFR values before and after adenosine administration, was also similar in diabetic and nondiabetic patients (8.4+/-6.0 vs. 8.4+/-5.5, P = 0.997). CONCLUSION: The presence of DM does not have a significant impact on FFR values in coronary stenoses of intermediate severity.
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Şahinarslan et al. (2009) conducted an observational in Coronary stenoses of intermediate severity (n=121). Diabetes mellitus vs. Absence of diabetes mellitus was evaluated on Fractional flow reserve (FFR) values (p=0.957). The presence of diabetes mellitus did not have a significant impact on fractional flow reserve values in coronary stenoses of intermediate severity compared to nondiabetic patients (P=0.957).
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