Key result
Progression of bronchial obstruction in COPD patients was associated with decreased coronary blood flow parameters and increased arterial stiffness, including higher augmentation and pulse pressures.
Why the study?
The combination of chronic obstructive pulmonary disease and cardiovascular disease leads to more severe disease progression and worse prognosis, prompting evaluation of cardiovascular status by pulse wave contour analysis across severities of bronchial obstruction.
Is the severity of bronchial obstruction associated with impaired central hemodynamics and increased arterial stiffness in patients with COPD?
Observational (n=60)
Is the severity of bronchial obstruction associated with impaired central hemodynamics and increased arterial stiffness in patients with COPD?
Answers are grounded in this paper and cite their sources.
In patients with COPD, greater severity of bronchial obstruction is associated with increased arterial stiffness and impaired central hemodynamics, potentially explaining their higher cardiovascular risk.
The combination of chronic obstructive pulmonary disease and cardiovascular disease is an urgent public health problem, that determines more severe disease progression, worse prognosis for the patient. The aim of the work was to evaluate the status of the cardiovascular system performing a pulse wave contour analysis in patients with chronic obstructive pulmonary disease depending on the severity of bronchial obstruction. Material and Methods. Applanation tonometry was performed in 60 patients (56 men, age 63.5 [IQR 59; 70] years) with chronic obstructive pulmonary disease to assess central hemodynamic parameters. The severity of obstructive disorders was determined by spirometry after taking bronchodilator. Results. In case of progression of bronchial obstruction, a decrease in parameters characterizing coronary blood flow was detected, mainly determined by an increase in heart rate and by a decrease in the duration of diastole. In addition, higher values of augmentation pressure, corrected by heart rate of 75 bpm, pulse pressure, central pulse height at the point of maximum rise of direct pulse wave were determined in patients with more severe bronchial obstruction. These parameters indicate higher values of arterial stiffness in this group of patients. Conclusion. In patients with chronic obstructive pulmonary disease and high values of bronchial obstruction there is an imbalance in the ratio of myocardial load and actual blood supply, and increased arterial stiffness with impaired aortic damping function, that contributes to the development of cardiovascular disease in this group of patients. These factors may explain high prevalence of cardiovascular disease in this group of patients.
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Punin et al. (2020) conducted an observational in chronic obstructive pulmonary disease (n=60). Applanation tonometry was evaluated on Central hemodynamic parameters. Progression of bronchial obstruction in COPD patients was associated with decreased coronary blood flow parameters and increased arterial stiffness, including higher augmentation and pulse pressures.
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