Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology

Figures

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  Figure 4. Regional plots for associations between ASTN2 and (A) BMI, (B) adjusted for the primary SNP for BMI, (C) primary and secondary SNPs for BMI, primary SNP for (D) SBP/DBP, (E) WHRadjBMI, (F) neuroticism, (G) anhedonia, and (H) mood instability. Significance was set at p-value < 5.45 × 10−5 or −log10 > 4.26 (Horizontal yellow line). LD (r2) with the lead SNP are indicated by colour. Grey indicates that there is no LD information available.

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  Figure 5. Regional plots for associations between ASTN2 and (A) WHRadjBMI, adjusted for the primary SNP for (B) WHRadjBMI, (C) SBP/DBP, and (D) BMI, (E) neuroticism, (F) anhedonia and (G) mood instability. Significance was set at p-value < 5.45 × 10−5 or −log10 > 4.26 (Horizontal yellow line). LD (r2) with the lead SNP are indicated by colour. Grey indicates that there is no LD information available.

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  Figure 1. Regional plots for associations between ASTN2 and (A) SBP, (B) DBP, (C) BMI and (D) WHRadjBMI, (E) neuroticism, (F) anhedonia and (G) mood instability. Significance was set at p-value < 5.45 × 10−5 or −log10 > 4.26 (Horizontal yellow line). LD (r2) with the lead SNP are indicated by colour. Grey indicates that there is no LD information available.

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  Figure 2. Results of associations between ASTN2 and (A) SBP, adjusted for the primary SNP for (B) SBP/DBP, (C) BMI and (D) WHRadjBMI, (E) neuroticism, (F) anhedonia and (G) mood instability. Significance was set at p-value < 5.45 × 10−5 or −log10 > 4.26 (Horizontal yellow line). LD (r2) with the lead SNP are indicated by colour. Grey indicates that there is no LD information available.

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  Figure 3. Results of associations between ASTN2 and (A) DBP, adjusted for the primary SNP for (B) SBP/DBP, (C) primary and secondary SNPs for DBP, (D) primary SNP for BMI, (E) WHRadjBMI, (F) neuroticism, (G) anhedonia and (H) mood instability. Significance was set at p-value < 5.45 × 10−5 or −log10 > 4.26 (Horizontal yellow line). LD (r2) with the lead SNP are indicated by colour. Grey indicates that there is no LD information available.

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  Figure 6. Results of associations between ASTN2 and (A) neuroticism, adjusted for the primary SNP for (B) neuroticism, (C) primary and secondary SNPs for neuroticism, (D) primary SNP for SBP/DBP, (E) BMI, (F) WHRadjBMI, (G) anhedonia and (H) mood instability. Significance was set at p-value < 5.45 × 10−5 or −log10 > 4.26 (Horizontal yellow line). LD (r2) with the lead SNP are indicated by colour. Grey indicates that there is no LD information available.

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  Figure 7. Results of associations between ASTN2 and (A) anhedonia, adjusted for the primary SNP for (B) anhedonia, (C) primary and secondary SNPs for anhedonia, (D) primary SNP for SBP/DBP, (E) BMI, (F) WHRadjBMI, (G) neuroticism and (H) mood instability. Significance was set at p-value < 5.45 × 10−5 or −log10 > 4.26 (Horizontal yellow line). LD (r2) with the lead SNP are indicated by colour. Grey indicates that there is no LD information available.

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  Figure 8. Results of associations between ASTN2 and (A) mood instability, adjusted for the primary SNP for (B) mood instability, (C) primary and secondary SNPs for mood instability, (D) primary SNP for SBP/DBP, (E) BMI, (F) WHRadjBMI, (G) neuroticism and (H) anhedonia. Significance was set at p-value < 5.45 × 10−5 or −log10 > 4.26 (Horizontal yellow line). LD (r2) with the lead SNP are indicated by colour. Grey indicates that there is no LD information available.

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  Figure 9. LD Structure of the ASTN2 locus and associations with psychological and physical phenotypes.

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  Figure 10. Expression of ASTN2, (A) depends upon genotype of the WHRadjBMI lead, rs6478243, in adipose tissue, and (B) depends on the genotype of the anhedonia lead, rs144850429, in tibial nerve tissue, (C) in all tissues.