Key result
The 112G/A SNP in the KCNE1 gene and 198T/C SNP in the KCNE3 gene were significantly associated with an increased susceptibility to develop Ménière's disease compared to non-MD controls.
Why the study?
Are single nucleotide polymorphisms in KCNE1 and KCNE3 genes associated with susceptibility to Ménière's disease?
Population
63 definite Ménière's disease (MD) cases and 205 to 237 non-MD control subjects
Design
Case-control
Authors
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Supports genetic susceptibility in Ménière's disease; leaves open replication and clinical translation.
Case-Control
Are single nucleotide polymorphisms in KCNE1 and KCNE3 genes associated with susceptibility to Ménière's disease?
The 112G/A SNP in the KCNE1 gene and 198T/C SNP in the KCNE3 gene are associated with an increased susceptibility to developing Ménière's disease.
Doi et al. (2005) conducted a case-control in Ménière's disease. 112G/A SNP in KCNE1 and 198T/C SNP in KCNE3 vs. Non-MD control subjects was evaluated on Frequency of 112G/A SNP in KCNE1 and 198T/C SNP in KCNE3. The 112G/A SNP in the KCNE1 gene and 198T/C SNP in the KCNE3 gene were significantly associated with an increased susceptibility to develop Ménière's disease compared to non-MD controls.
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