Key result
A novel biophysically detailed computer model of teleost fish ventricular myocytes successfully generated action potentials that quantitatively matched available experimental data.
Why the study?
Models of fish cardiomyocytes are less developed, and rising sea temperatures from global warming can impact cardiac arrhythmias and sudden death in fish.
A novel mathematical model of teleost fish ventricular action potentials was successfully developed and validated, providing a framework to investigate the effects of temperature changes on fish cardiac electrophysiology.
May facilitate fish cardiac electrophysiology research; leaves open translation to mammalian or human models.
Mathematical modelling, combined with experimental approaches, has become a powerful method for investigating the heart functions. So far, different models of cardiac electrical activities of variant species have been developed. However, models of fish cardiomycytes are less developed. Given the prominent problem of global warming, sea temperature changes will have a significant impact on the development of cardiac arrhythmias in the fish heart, leading to their sudden death, which may impose a heavy burden to the economy of the society. This study aimed to develop a biophysically detailed computer model for the teleost fish ventricular myocytes in warm acclimation (18 °C). A set of Hodgkin-Huxley (HH) formulations have been developed for the major ion currents that were based on experimental data from different teleost species. With a series of supra-threshold stimuli (amplitude of -41 pA/pF; duration of 10 ms and time interval (between two successive stimuli) of 1000 ms) the teleost fish model generates a successful sequence of action potentials (APs). The characteristics of the (APs) matched quantitatively the available experimental findings. In conclusion, a mathematical model for the electrical action potential of the teleost fish cardiac myocytes has been developed and validated.
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Naser et al. (2018) studied Cardiac electrophysiology in teleost fish. Biophysically detailed computer model vs. Experimental data was evaluated on Simulation of action potentials. A novel biophysically detailed computer model of teleost fish ventricular myocytes successfully generated action potentials that quantitatively matched available experimental data.
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