Key result
Acute alcohol intoxication significantly increased mean QT interval dispersion compared to controls (48.6 vs 40.8 msec, p=0.019) and decreased significantly by discharge.
Why the study?
Does acute alcohol intoxication increase QT interval dispersion?
Observational (n=111)
Does acute alcohol intoxication increase QT interval dispersion?
Acute alcohol intoxication is associated with a transient increase in QT interval dispersion, which may contribute to an increased risk of arrhythmias.
Acute intoxication was associated with transient QT dispersion increase; hypothesis-generating for arrhythmia risk, prospective studies needed.
Alcohol intoxication is probably the most common intoxication worldwide. Some studies have suggested an association between QT interval dispersion (QTd) and the risk of arrhythmias. The aim of this report is to assess how alcohol in potential lethal blood concentrations affects QTd. Eighty-four patients were included in analyses. QTd at admittance was compared with a control group (n = 27) and with QTd at discharge. Univariate and multivariate logistic regression analyses were performed in order to explore odds ratio for dispersion including several variables. Mean QTd was 48.6 msec (SD: 13.9) in alcohol intoxicated patients compared to 40.8 msec (SD: 16.5) in the controls (p = 0.019). QTd was larger at admission than at discharge in patients with alcohol intoxication (49.7 msec (13.3) vs. 41.9 (13.8). P = 0.032). Mean blood alcohol level was 2.9‰ in the study group.
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Willy Aasebø (2016) conducted an observational in Acute alcohol intoxication (n=111). Acute alcohol intoxication vs. Healthy controls and patients at discharge was evaluated on QT interval dispersion (QTd) (p=0.019). Acute alcohol intoxication significantly increased mean QT interval dispersion compared to controls (48.6 vs 40.8 msec, p=0.019) and decreased significantly by discharge.
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