Development of Heterocyclic Multicomponent Reactions through Guided Exploration: Direct, Reasonable and Unpredictable Processes

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This Account summarizes the research of the group on the multicomponent reactions arena with fundamental heterocycles as substrates, using mechanistic considerations to hypothesize new processes and to rationalize results. Biomedical applications of the ensuing adducts were also envisaged, which brought about interesting discoveries. 1 Introduction and Context 2 The Beginnings: Unexplored Heterocyclic Substrates 3 Interrupted Processes 4 Multiple Multicomponent Reactions: Problem of Selectivity 5 Extended Multicomponent Reactions 6 Conclusions and Wishes