An increase in left ventricular mass over time within the normal range was significantly associated with an augmented risk of cardiovascular mortality over 18.5 years (HR 1.2; 95% CI 1.0-1.5).
Cohort
Does an increase in left ventricular mass over time increase the risk of long-term cardiovascular mortality in a general population with normal baseline LVM?
An increase in left ventricular mass over time, even while remaining within the normal range, is associated with an augmented risk of long-term cardiovascular mortality.
Effect estimate: HR 1.2 (95% CI 1.0-1.5)
BACKGROUND: Left ventricular hypertrophy (LVH) is an independent predictor of cardiovascular events, and evidence has been obtained that an increase of a normal left ventricular mass (LVM) or new-onset LVH over time augments cardiovascular outcomes. METHODS: We addressed this issue in a sample of a general population at relatively low cardiovascular risk. We analyzed subjects with normal echocardiographic LVM enrolled in the PAMELA (Pressioni Arteriose Monitorate E Loro Associazioni) study to follow the increase of LVM over time and assess the prognostic impact of this change on the incidence of cardiovascular events (mean follow-up 18.5 years). RESULTS: change exhibited an association with the cardiovascular risk mortality during the following 18.5 years, and the association remained significant after adjustment for confounders (hazard ratio, 1.2 1.0-1.5). Similar findings were obtained for LVM in absolute values or indexed for height. The association was seen in both genders, but the link with the cardiovascular risk was statistically significant in males only. CONCLUSIONS: Thus, although over 10 years, the LVM increase does not reach a LVH status, it is associated with an augmented cardiovascular mortality risk. This suggests that it might be important to consider periodical LVM assessment, even when LVM is within the normal range, to timely detect its increase and cope with the need of cardiovascular risk restratification.
Bombelli et al. (Wed,) conducted a cohort in General population at relatively low cardiovascular risk. Increase in left ventricular mass was evaluated on Cardiovascular mortality (HR 1.2, 95% CI 1.0-1.5). An increase in left ventricular mass over time within the normal range was significantly associated with an augmented risk of cardiovascular mortality over 18.5 years (HR 1.2; 95% CI 1.0-1.5).
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