What is the clinical evidence from this study?

Study design: Other. Population: Cisplatin-induced cardiotoxicity (n=42). Intervention: Lycopene-Cub-NPs vs. Cisplatin alone. Primary outcome: Serum LDH level (57.36% reduction, p=<0.05).

What does this research mean for the field?

Lycopene cubosomal nanoparticles mitigate cisplatin-induced cardiotoxicity in vivo more effectively than free lycopene, acting through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms involving the NF-ҡB/HO-1 and Sirt1/AMPK/PGC1-α signaling pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 19, 2025BMC BiotechnologyOpen Access

Protective effect of Lycopene/Lycopene cubosomal nanoparticles against cisplatin-induced cardiotoxicity: the function of NF-ҡB/HO-1 and Sirt1/AMPK/PGC1-α signaling pathways

Q: What are the key findings of this study?

Lycopene-Cub-NPs mitigated cisplatin-induced cardiotoxicity in rats by significantly reducing serum LDH and CK-MB levels by 57.36% and 62.49%, respectively, compared to cisplatin alone.

Q: What does this research mean for the field?

Lycopene cubosomal nanoparticles mitigate cisplatin-induced cardiotoxicity in vivo more effectively than free lycopene, acting through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms involving the NF-ҡB/HO-1 and Sirt1/AMPK/PGC1-α signaling pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Lycopene-Cub-NPs mitigate cisplatin-induced cardiotoxicity in rats, cutting serum LDH by ~57%.

57.36% reduction
P<0.05
n=42

Why the study?

To explore the novel application of a lycopene nanoformulation to reduce cisplatin-induced cardiotoxicity and determine the underlying cardioprotective mechanisms.

Does Lycopene-Cub-NPs prevent cisplatin-induced cardiotoxicity in a rat model?

Population

Rats

Comparison

Lycopene-Cub-NPs + Cis vs Lycopene Free + Cis, Cis alone, and control groups

Design

Animal study with seven allocated groups

Authors

BABadriyah S. AlotaibiPrincess Nourah bint Abdulrahman University TEThanaa A. El‐MasrySinai University MEMaisra M. El‐BousearyTanta University

Discussion

Member takes

Implication

Hypothesis-generating in rat cardiotoxicity models; leaves open translation to cisplatin-treated patients.

Structured PICO

Does Lycopene-Cub-NPs prevent cisplatin-induced cardiotoxicity in a rat model?

Population

42 adult male Wistar albino rats, weighing 150-170 g

Intervention

Lycopene-Cub-NPs (lycopene nanoformulation) 10 mg/kg oral daily for 30 days, with a single dose of Cisplatin 10 mg/kg I.P. on day 27

Comparator

Cisplatin alone (0.5% CMC oral daily for 30 days + Cisplatin 10 mg/kg I.P. on day 27), Lycopene Free (10 mg/kg oral daily for 30 days + Cisplatin), Control (0.5% CMC oral daily), and Control polymer

Outcome

Heart damage markers (CK-MB and LDH) and oxidative stress markers in heart tissue at 30 dayssurrogate

Main Result

Effect estimate: 57.36% reduction

p-value: p=<0.05

Lycopene cubosomal nanoparticles mitigate cisplatin-induced cardiotoxicity in rats more effectively than free lycopene via antioxidant, anti-inflammatory, and anti-apoptotic pathways.

Cite This Study

Alotaibi et al. (2025) studied Cisplatin-induced cardiotoxicity (n=42). Lycopene-Cub-NPs vs. Cisplatin alone was evaluated on Serum LDH level (57.36% reduction, p=<0.05). Lycopene-Cub-NPs mitigated cisplatin-induced cardiotoxicity in rats by significantly reducing serum LDH and CK-MB levels by 57.36% and 62.49%, respectively, compared to cisplatin alone.

synapsesocial.com/papers/6a1b461b39ea7417dc42a4d9 https://doi.org/10.1186/s12896-025-01054-5

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Protective effect of Lycopene/Lycopene cubosomal nanoparticles against cisplatin-induced cardiotoxicity: the function of NF-ҡB/HO-1 and Sirt1/AMPK/PGC1-α signaling pathways

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Protective effect of Lycopene/Lycopene cubosomal nanoparticles against cisplatin-induced cardiotoxicity: the function of NF-ҡB/HO-1 and Sirt1/AMPK/PGC1-α signaling pathways

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

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