Key result
Fetal magnetocardiography and echocardiography successfully diagnosed fetal KCNQ1-variant long QT syndrome, altering antenatal management and leading to safe delivery and postnatal confirmation.
Case Report (n=1)
Fetal magnetocardiography can aid in the diagnosis of fetal long QT syndrome, guiding antenatal management and potentially improving fetal and postnatal outcomes.
May inform select high-risk fetal LQTS cases; leaves open need for prospective validation before wider use.
A pregnant woman with KCNQ1 variant long QT syndrome (LQTS) underwent fetal magnetocardiography (fMCG) after atrioventricular (AV) block was noted during fetal echocardiogram-atypical for LQTS type 1. Concern for fetal LQTS on fMCG prompted monitoring of maternal labs, change of maternal beta blocker therapy, and frequent fetal echocardiograms. Collaboration between obstetricians, neonatologists, and pediatric cardiologists ensured safe delivery. Beta blocker therapy was initiated after birth, and postnatal evaluation confirmed genotype and phenotype positive LQTS in the infant. Our experience suggests diagnosis and evaluation of fetal LQTS can alter antenatal management to reduce risk of poor fetal and postnatal outcomes.
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Desai et al. (2020) conducted a case report in KCNQ1-variant long QT syndrome (n=1). Fetal magnetocardiography (fMCG) and fetal echocardiography was evaluated on Diagnosis and postnatal confirmation of LQTS. Fetal magnetocardiography and echocardiography successfully diagnosed fetal KCNQ1-variant long QT syndrome, altering antenatal management and leading to safe delivery and postnatal confirmation.
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