The highest tertile of the triglyceride-glucose index was associated with a 1.16 times higher prevalence of symptomatic coronary artery disease compared to the lowest tertile.
Cross-Sectional (n=2,330)
Yes
Is a higher triglyceride-glucose (TyG) index associated with an increased prevalence of symptomatic coronary artery disease in patients with established cardiovascular disease?
A higher triglyceride-glucose (TyG) index is associated with a higher prevalence of symptomatic coronary artery disease and worse cardiometabolic risk profiles in secondary care patients.
Effect estimate: PR 1.16 (95% CI 1.01-1.33)
p-value: p=0.015
BACKGROUND: The triglyceride-glucose index (TyG index) is a tool for insulin resistance evaluation, however, little is known about its association with coronary artery disease (CAD), which is the major cardiovascular death cause, and what factors may be associated with TyG index. OBJECTIVE: To evaluate the association between the TyG index and the prevalence of CAD phases, as well as cardiovascular risk factors. METHODS: The baseline data of patients in secondary care in cardiology from Brazilian Cardioprotective Nutritional Program Trial (BALANCE Program Trial) were analyzed. Anthropometric, clinical, socio-demographic and food consumption data were collected by trained professionals. The TyG index was calculated by the formula: Ln (fasting triglycerides (mg/dl) × fasting blood glucose (mg/dl)/2) and regression models were used to evaluate the associations. RESULTS: We evaluated 2330 patients, which the majority was male (58.1%) and elderly (62.1%). The prevalence of symptomatic CAD was 1.16 times higher in patients classified in the last tertile of the TyG index (9.9 ± 0.5) compared to those in the first tertile (8.3 ± 0.3). Cardiometabolic risk factors were associated with TyG index, with the highlight for higher carbohydrate and lower lipid consumption in relation to recommendations that reduced the chance of being in the last TyG index tertile. CONCLUSION: The TyG index was positively associated with a higher prevalence of symptomatic CAD, with metabolic and behavioral risk factors, and could be used as a marker for atherosclerosis. Trial registration ClinicalTrials.gov identifier: NCT01620398. Registered 15 June, 2012.
Silva et al. (2019) conducted a cross-sectional in Cardiovascular disease (n=2,330). Triglyceride-glucose index (highest tertile) vs. Triglyceride-glucose index (lowest tertile) was evaluated on Prevalence of symptomatic coronary artery disease (PR 1.16, 95% CI 1.01-1.33, p=0.015). The highest tertile of the triglyceride-glucose index was associated with a 1.16 times higher prevalence of symptomatic coronary artery disease compared to the lowest tertile.