Key result
Anti-endothelial cell antibodies drive vascular inflammation, thrombosis, and endothelial dysfunction in vasculitis.
Anti-endothelial cell antibodies play a key pathological role in vasculitis by inducing endothelial cell damage, inflammation, coagulation, and altering mechanical properties.
Vasculitis is a group of syndromes characterized by inflammation, presence of autoantibodies and endothelial cells (ECs) damage, which lead to stenosis or occlusion of the vascular lumen. Anti-endothelial cell antibodies (AECAs) are a heterogeneous group of autoantibodies in vasculitis. AECAs bind to antigens and membrane-bound proteins of ECs, inducing inflammation, coagulation, and apoptosis. In this review, we discuss the pathological role of AECAs in different types of vasculitis. In addition, AECAs potentially induce alterations of ECs mechanical properties, and subsequently promotes angiogenic phenotypes in the occurrence of vasculitis.
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Zhang et al. (2025) conducted a review in Vasculitis. Anti-endothelial cell antibodies (AECAs) was evaluated. Anti-endothelial cell antibodies (AECAs) bind to endothelial cells, inducing inflammation, coagulation, apoptosis, and potentially promoting angiogenic phenotypes in vasculitis.
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