Key result
Additive genetic contribution explains a substantial proportion of the variability of aortic root size (h2=0.51, P<0.001) independent of age, sex, body size, and blood pressure.
Why the study?
Does heredity influence aortic root size in American Indians?
Population
1,373 American Indian participants in the second Strong Heart Study examination who had ≥1 family member in…
Design
Cross-sectional
Authors
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Supports substantial heritability of aortic root size in American Indians; hypothesis-generating and should not yet change screening practice.
Cohort (n=1,373)
Yes
Does heredity influence aortic root size in American Indians?
Effect estimate: h2 0.51
p-value: p=<0.001
Heredity explains a substantial proportion of the variability of aortic root size independent of age, sex, body size, and blood pressure, suggesting echocardiographic screening of family members may be beneficial.
Bella et al. (2002) conducted a cohort in Aortic root size (n=1,373). Heritability was evaluated on Heritability of echocardiographically derived aortic root diameter (h2 0.51, p=<0.001). Additive genetic contribution explains a substantial proportion of the variability of aortic root size (h2=0.51, P<0.001) independent of age, sex, body size, and blood pressure.
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