Why the study?
Circulating endothelial microvesicles may serve as a key biomarker and mediator of vascular dysfunction in obesity.
Elevated circulating endothelial microvesicles may serve as a biomarker and mechanistic link for vascular dysfunction and cardiovascular risk in adults with obesity.
Elevated EMVs may mark endothelial dysfunction in obesity; hypothesis-generating for prognostic value and therapeutic targeting.
Circulating endothelial microvesicles (EMVs) may serve as a key biomarker and mediator of vascular dysfunction in obesity. This study demonstrates that EMV levels are markedly higher in adults with obesity compared with adults with normal weight. Elevated EMVs were associated with impaired endothelial vasodilation and heightened endothelin-1-mediated vasoconstriction. These findings highlight a potential mechanistic link between obesity and cardiovascular disease risk, emphasizing the role of EMVs in vascular health.
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Garcia et al. (2025) studied this question.
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