Demonstrates integrated extra- and intracellular bioelectronics in a heart-on-a-chip platform under acute hypoxia, highlighting advanced mapping capabilities for disease modeling and drug testing.
channels that promote membrane repolarization. Significantly, both extra- and intracellular devices could be multiplexed, enabling mapping capabilities unachievable by other electrophysiological tools. Our platform represents a significant advance toward understanding electrophysiological responses to hypoxia and could be applicable to disease modeling and drug development.
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Liu et al. (2020) studied this question.
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