Exploring the Differential Recognition of DNA G‐Quadruplex Targets by Small Molecules Using Dynamic Combinatorial Chemistry

Tuning affinities: Dynamic combinatorial chemistry has been employed to explore the effect of chemical modifications on the DNA G-quadruplex binding properties of an oxazole-based peptide macrocycle. Two dynamic libraries of molecules, containing cationic and carbohydrate motifs, respectively, were screened by using structurally diverse nucleic acid targets (see scheme; each colored shape represents a cation or carbohydrate). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705589_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.