Why the study?
Does antidepressant use or elevated depression symptoms increase the risk of developing diabetes in participants of the Diabetes Prevention Program?
Population
3,187 participants in the Diabetes Prevention Program randomized to intensive lifestyle, metformin, or placebo
Comparison
Elevated depression symptoms or antidepressant… vs No elevated depression symptoms or no…
Design
Cohort
Follow-up
average 3.2 years
Authors
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Antidepressant use signals higher diabetes risk absent metformin; leaves open confounding versus causality and needs prospective confirmation.
Does antidepressant use or elevated depression symptoms increase the risk of developing diabetes in participants of the Diabetes Prevention Program?
Antidepressant use, but not elevated depression symptoms, is independently associated with an increased risk of developing diabetes in at-risk individuals not treated with metformin.
Rubin et al. (2008) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: