Why the study?
Genome-wide studies have revealed heritable risk factors for ischaemic stroke, but the broader utility of these generated data across other disciplines remains to be explored.
This review highlights how genome-wide study data in ischaemic stroke can be utilized beyond finding genes, such as understanding biological mechanisms, determining causality with other diseases, and identifying potential drug targets.
Broadens GWAS applications in ischaemic stroke beyond gene discovery; leaves open clinical translation of targets.
Ischaemic stroke is a complex disease with some degree of heritability. This means that heritability factors, such as genetics, could be risk factors for ischaemic stroke. The era of genome-wide studies has revealed some of these heritable risk factors, although the data generated by these studies may also be useful in other disciplines. Analysis of these data can be used to understand the biological mechanisms associated with stroke risk and stroke outcome, to determine the causality between stroke and other diseases without the need for expensive clinical trials, or to find potential drug targets with higher success rates than other strategies. In this review we will discuss several of the most relevant studies regarding the genetics of ischaemic stroke and the potential use of the data generated.
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Gallego-Fábrega et al. (2022) studied this question.
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