What does this research mean for the field?

The addition of biomarkers of endothelial dysfunction and inflammation, specifically E-selectin, serum albumin, and leukocyte count, to traditional risk factors significantly improves the prediction of incident type 2 diabetes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

March 20, 2008ObesityOpen Access

Additional Contribution of Emerging Risk Factors to the Prediction of the Risk of Type 2 Diabetes: Evidence From the Western New York Study

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Why the study?

Does the addition of biomarkers of endothelial function and inflammation to traditional risk factors improve the prediction of incident type 2 diabetes?

Structured PICO

Does the addition of biomarkers of endothelial function and inflammation to traditional risk factors improve the prediction of incident type 2 diabetes?

Population

1,455 participants from the Western New York Study, free of type 2 diabetes at baseline. 61 incident cases were identified and individually matched with up to three controls.

Intervention

Addition of biomarkers of endothelial function and inflammation (E-selectin, serum albumin, and leukocyte count) to traditional risk factor prediction models

Comparator

Prediction model using only traditional risk factors (age, family history of diabetes, smoking, drinking status, and BMI)

Outcome

Incident type 2 diabetes (fasting glucose >125 mg/dl or on antidiabetic medication) over 5.9 years of follow-uphard clinical

Biomarkers of endothelial dysfunction and inflammation, specifically E-selectin, serum albumin, and leukocyte count, significantly improve the prediction of incident type 2 diabetes beyond traditional risk factors.

Discussion

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Implication

May enhance T2D prediction in obesity; hypothesis-generating and requires prospective validation before clinical use.

Cite This Study

Stranges et al. (2008) studied this question.

synapsesocial.com/papers/6a1bcf8400ee29383e9cf389 https://doi.org/10.1038/oby.2008.59

Topics

Women and heart disease Sermorelin

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Additional Contribution of Emerging Risk Factors to the Prediction of the Risk of Type 2 Diabetes: Evidence From the Western New York Study

Structured PICO

Discussion

Implication

Cite This Study

Topics

Additional Contribution of Emerging Risk Factors to the Prediction of the Risk of Type 2 Diabetes: Evidence From the Western New York Study

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider