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December 1, 1994CirculationOpen Access

Relative effects of alpha 1-adrenoceptor blockade, converting enzyme inhibitor therapy, and angiotensin II subtype 1 receptor blockade on ventricular remodeling in the dog.

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Why the study?

Do pharmacological inhibitors (ACE inhibitors, alpha-1 blockers, AT1 receptor blockers) prevent ventricular remodeling in a canine model of myocardial injury?

Population

Canine model of localized myocardial injury resulting from transmyocardial DC shock

Comparison

Zofenopril, terazosin, full-dose ramipril… vs Control group

Design

Preclinical

Follow-up

16 weeks

Authors

KMKenneth McDonaldHeart Failure & TransplantMGMichael GarrTwin Cities OrthopedicsPCPeter F. CarlyleUniversity of Minnesota

Discussion

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Implication

Zofenopril attenuated post-injury remodeling in this canine model; hypothesis-generating for human ventricular remodeling prevention.

Structured PICO

Do pharmacological inhibitors (ACE inhibitors, alpha-1 blockers, AT1 receptor blockers) prevent ventricular remodeling in a canine model of myocardial injury?

P
Population
Canine model of localized myocardial injury resulting from transmyocardial DC shock
I
Intervention
Zofenopril, terazosin, full-dose ramipril, low-dose ramipril, or angiotensin II subtype 1 receptor blocker
C
Comparator
Control group
O
Outcome
Left ventricular mass (LVM) and end-diastolic volume (LVV) at 16 weekssurrogate

High-dose ACE inhibitor therapy prevents progressive structural changes after localized myocardial damage in a canine model, whereas alpha-1 adrenoceptor blockade and AT1 receptor blockade do not.

Cite This Study

McDonald et al. (1994) studied this question.

synapsesocial.com/papers/6a1bcfaffc87fd06169cda64https://doi.org/10.1161/01.cir.90.6.3034
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.1990 · 2,883 citations
  2. 2Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.1991 · 2,041 citations
  3. 3Alpha 1-adrenergic stimulation of rat myocardial cells increases protein synthesis1986 · 76 citations
  4. 4Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.1989 · 2,172 citations
  5. 5The renin system: Variations in man measured by radioimmunoassay or bioassay1972 · 383 citations