Shows high-yield hydroarylation in a diverse substrate set, indicating effective catalysis.
The cocatalytic reductive cross-coupling of unactivated alkynes with aryl bromides is reported, using 2 mol % Pd(PPh3)4 and 10 mol % Cp2ZrCl2 in combination with a hydrosilane reductant. Hydroarylated products are furnished in upward of 91% yield across 25 elaborated substrates, including those containing unprotected alcohols, esters, amides, and terminal alkenes. Syn-selective hydrozirconation of alkyne substrates prior to transmetalation ensures exceptional (>20:1) (E)-selectivity across all alkene products. Further, this protocol was successfully implemented on gram scale without loss of efficiency or selectivity.
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Erzuah et al. (2026) studied this question.
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