Enzyme-Assisted Extraction of Polysaccharides from Steam-Exploded Ganoderma lucidum and Its Yield, Structural Characterisation, and Immunomodulatory Activity

May 29, 2026MoleculesOpen Access

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The study aims to develop an innovative enzymatic extraction method for increasing polysaccharide yields from Ganoderma lucidum and evaluate their structural and immunomodulatory properties.
Utilized steam-exploded Ganoderma lucidum for enzyme-assisted extraction of polysaccharides.
Characterized the purified polysaccharide fraction, GLP-L, using methylation, NMR spectroscopy, and FTIR.
Evaluated immunomodulatory effects through the RAW264.7 macrophage model.
Achieved a crude polysaccharide yield of 15.39%, significantly higher than the traditional water method yield of 2.21%.
GLP-L had a molecular weight of 5.59 × 10^6 Da and contained D-mannose (52.76 mol%), D-glucose (36.98 mol%), D-xylose (6.39 mol%), and D-galactose (3.87 mol%).
Demonstrated enhanced phagocytic activity and increased production of nitric oxide and cytokines in the macrophage model.

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Demonstrates enhanced yield and immunomodulatory activity of polysaccharides in Ganoderma lucidum, highlighting a novel extraction approach.

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Liu et al. (2026) studied this question.

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