Pharmacology of Estrogen-Related Receptors (ERRs) Agonists

Q: What does this research mean for the field?

Estrogen-related receptors (ERRs), comprising isoforms ERRα, ERRβ, and ERRγ, share structural homology with classical estrogen receptors but do not bind endogenous estrogens, and can be targeted by specific pharmacological agonists. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Mohammad Radwan; Soumitra Guin; Thomas P. Burris

doi:10.1039/d6cb00077k

January 1, 2026RSC Chemical BiologyOpen Access

Pharmacology of Estrogen-Related Receptors (ERRs) Agonists

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Key Points

This research aims to characterize the pharmacological properties of estrogen-related receptors (ERRs) and their agonists. Understanding their role could facilitate new therapeutic strategies.
Reviewed current literature on ERRs and their pharmacological effects.
Analyzed structural homology between ERRs and classical estrogen receptors.
Discussed potential therapeutic applications of ERR agonists.
Identified significant structural similarities between ERRs and classical estrogen receptors.
Highlighted the prospective use of ERR agonists in various therapeutic contexts.
Indicated potential pathways through which ERRs could modulate physiological responses.

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Implication

This review explores the pharmacology of estrogen-related receptors agonists, highlighting their potential therapeutic applications.

Abstract

The estrogen-related receptors (ERRs) are a subfamily of orphan nuclear receptors that share high structural homology with classical estrogen receptors but do not bind endogenous estrogens. The three isoforms—ERRα, ERRβ,...

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Cite This Study

Radwan et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd0df5783ba022b6fc927 https://doi.org/10.1039/d6cb00077k

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Pharmacology of Estrogen-Related Receptors (ERRs) Agonists

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Pharmacology of Estrogen-Related Receptors (ERRs) Agonists

Key Points

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Implication

Abstract

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