Identification of Streptococcus pyogenes isolates with reduced beta-lactam susceptibility in a cohort of children with pharyngitis

Daniel B. Amusin; Lacy M. Simons; Dulce S. Garcia; Samuel W. M. Gatesy; Sophia Nozick; Jennifer Sheridan; Alan R. Hauser; Emma Office; Preeti Jaggi; David B. Williams; Rachel J. Tanz; Yiannis Katsogridakis; Larry K. Kociolek; Ami B. Patel; Stanford T. Shulman; Judith A. Guzman‐Cottrill; Robert R. Tanz; Egon A. Ozer

doi:10.1128/aac.00354-26

Key Points

This study aims to identify bacterial variants that exhibit reduced susceptibility to beta-lactam antibiotics in children with pharyngitis.
Analyzed sequences of penicillin-binding protein 2x (PBP2x) from 902 isolates of Streptococcus pyogenes.
Performed susceptibility testing for penicillin and ampicillin on identified variants and wild-type isolates.
Identified 25 pharyngeal isolates carrying variants associated with reduced susceptibility.
PBP2x variant isolates displayed reduced susceptibility to penicillin and ampicillin compared to wild-type, with specific metrics undetermined.
Twenty-five isolates were confirmed to carry the PBP2x variants linked to lower antibiotic effectiveness.
Findings reveal a potential increase in treatment failure risk for certain children with pharyngitis.

Implication

Identifies beta-lactam susceptibility variants in children with pharyngitis, suggesting potential treatment challenges.

Abstract

We investigated sequences of the penicillin-binding protein 2x (PBP2x) among 902 Streptococcus pyogenes isolates from children with pharyngitis. Twenty-five pharyngeal isolates carried variants associated with reduced β-lactam susceptibility. Penicillin and ampicillin susceptibility testing confirmed reduced susceptibility among PBP2x variant isolates relative to those with the wild-type sequence.

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Cite This Study

Amusin et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd1745783ba022b6fcf9e https://doi.org/10.1128/aac.00354-26

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Identification of Streptococcus pyogenes isolates with reduced beta-lactam susceptibility in a cohort of children with pharyngitis

Key Points

Implication

Abstract

Discussion

Cite This Study

Identification of Streptococcus pyogenes isolates with reduced beta-lactam susceptibility in a cohort of children with pharyngitis

Key Points

Implication

Abstract

Discussion

Cite This Study

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