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May 31, 2026Dermatitis

Chronic Spontaneous Urticaria Combined Atopic Dermatitis/Other Atopic Comorbidities: Clinical Characteristics, Therapeutic Response to Omalizumab, and Drug Survival

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Authors

RLRuiguo LiACAnqi ChenXYXianjie Yang

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Overview

Retrospective study compares omalizumab response in chronic spontaneous urticaria with atopic conditions, suggesting need for tailored management.

Key Points

  • The aim is to compare clinical profiles and omalizumab treatment outcomes among CSU patients with and without atopic comorbidities.
  • Single-center retrospective study of 381 CSU patients treated with omalizumab for ≥6 months.
  • Patients were grouped based on atopic comorbidities: AD, OACs, and no comorbidities.
  • Clinical features and treatment responses were analyzed for these groups.
  • CSU-OACs had earlier onset (P=0.033) and higher angioedema prevalence (P=0.042).
  • Faster response speed observed in CSU-OACs (P=0.019), with more adverse events (P=0.004).
  • Drug survival was higher in CSU-OACs compared to CSU-NA group (P=0.007).

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd1745783ba022b6fd0c3https://doi.org/10.1177/17103568261455284
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical factors as predictors of the development of severe recurrence of chronic spontaneous urticaria after completion of omalizumab therapy2024
  2. 2Clinical Factors Associated With High‐Dose Omalizumab Use in Chronic Spontaneous Urticaria: A Retrospective Real‐World Study2026
  3. 3Disparities in chronic spontaneous urticaria: Eligibility for drug reimbursement associated with clinical outcomes2024 · 3 citations
  4. 4Co-existence of chronic spontaneous urticaria with atopic dermatitis: clinical and immunological perspectives2025
  5. 5P093 Bespoke omalizumab prescribing in chronic spontaneous urticaria2024