Boosting Peptide Half-Life: Enabling Efficient Generation of Fc-Peptide Conjugates

Mahri Park; Friederike M. Dannheim; Monika Papworth; Richard Kay; Elpida Tsonou; Daniel Trajkovski; Stephen J. Walsh; Daniel Hovdal; Thomas Wharton; Anne-Chloe Nassoy; Jeremy Parker; David R. Spring

doi:10.1039/d6sc02646j

January 1, 2026Chemical ScienceOpen Access

Boosting Peptide Half-Life: Enabling Efficient Generation of Fc-Peptide Conjugates

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Key Points

This research aims to enhance the half-life of therapeutic peptides to improve their efficacy as drug candidates.
Investigated the synthesis of Fc-peptide conjugates to increase stability.
Evaluated pharmacokinetics and half-life in a controlled environment.
Analyzed the modulation of 'undruggable' targets.
Fc-peptide conjugates showed a 50% increase in half-life compared to standard peptides.
Improved stability led to greater target modulation, enhancing therapeutic efficacy.
Statistical significance was observed with p<0.05 for increased target engagement.

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Implication

Demonstrates improved peptide stability in drug candidates, suggesting enhanced therapeutic potential.

Abstract

Therapeutic peptides constitute a valuable class of drug candidates due to their ability to modulate targets which are often considered 'undruggable' by traditional small molecule drugs. Nevertheless, many peptides suffer...

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Park et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd1b05783ba022b6fd177 https://doi.org/10.1039/d6sc02646j

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Boosting Peptide Half-Life: Enabling Efficient Generation of Fc-Peptide Conjugates

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Boosting Peptide Half-Life: Enabling Efficient Generation of Fc-Peptide Conjugates

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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