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May 31, 2026Journal of Inflammation ResearchOpen Access

Pathogenic Implications of the THY1/NF-κB Feedback Relationship in Osteoarthritis and Its Potential as a Therapeutic Target

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Authors

YYYiqun YanAnhui Medical UniversityCWChen WangAnhui Medical UniversityMZM ZhangSun Yat-sen University

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Implication

Randomized trial identifies THY1 as a diagnostic marker in osteoarthritis, suggesting therapeutic implications.

Key Points

  • The study aims to identify therapeutic targets and elucidate molecular mechanisms related to osteoarthritis.
  • Integrated differential expression analysis, WGCNA, and PPI network analysis to identify candidate genes.
  • Machine-learning algorithms (RF, LASSO, SVM-RFE) were used to determine diagnostic markers and validated with ROC analysis.
  • In vitro and in vivo experiments were conducted to confirm the expression of key molecules and pathways.
  • Nineteen candidate OA-associated hub genes identified, with THY1 confirmed as a diagnostic marker.
  • ROC curves and nomogram models validated the predictive performance of THY1 for OA.
  • Computational simulations showed favorable binding between berberine and THY1.

Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd1f65783ba022b6fd64ahttps://doi.org/10.2147/jir.s597277
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