Evaluation of the Relationship Between Intrahepatic Cholestasis of Pregnancy and Serum Vitamin D, Folate, and Vitamin B12 Levels

Background: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-related liver disease that occurs during the third trimester. Both maternal and fetal complications are common in pregnant women with cholestasis. The risk and severity of complications increase with higher serum bile acid levels. 25-hydroxycholecalciferol [25(OH)D3], folate, and vitamin B12 supplementation during pregnancy improves maternal and fetal outcomes. This study aimed to evaluate the association between serum 25(OH)D3, folate, and vitamin B12 levels in pregnant women with and without ICP. Data from 29 pregnant women diagnosed with ICP and 85 healthy pregnant women admitted to Izmir Atatürk Training and Research Hospital were compared. Methods: Izmir Atatürk Training and Research Hospital’s electronic data record system was reviewed retrospectively, and vitamin D, folate, and vitamin B12 levels, which are routinely screened during pregnancy, were determined for both groups. Results: Contrary to previous studies, no significant differences were found between the serum vitamin D, folate, or vitamin B12 levels between pregnant women with ICP and healthy pregnant women. These values, except for folate, were below the reference range in both groups. Conclusions: Limited access to a healthy and balanced diet in our country, irregular use of vitamin supplements, and seasonal conditions may have influenced our results.